Reishi mushroom extract and immune support by Dr Jame Meschino

While researching my own thesis for my Masters program, I decided to tap on the University electronic library  resources. A single type of the word ‘ Reishi’ churned out so many articles and research documents I gave up reading after … Continue reading

Reishi Inhibits Cancer Cell Growth in Inflammatory Breast Cancer.

As always, I’m constantly on the lookout for current research and credible info on Reishi and its benefits towards all of us. This abstract below is from a research study done on breast cancer cells, conducted by the Department of Biochemistry and Department of Physiology, Universidad Central del Caribe, School of Medicine, Bayamon, Puerto Rico. Published Sept 2011. Because it contain medical mumbo-jumbo which might bore you from reading further, I’ve highlighted the key findings in BOLD.

Abstract

Inflammatory breast cancer (IBC) is the most lethal and least understood form of advanced breast cancer. Its lethality originates from its nature of invading the lymphatic system and absence of a palpable tumor mass. Different from other metastatic breast cancer cells, IBC cells invade by forming tumor spheroids that retain E-cadherin-based cell-cell adhesions. Herein we describe the potential of the medicinal mushroom Ganoderma lucidum (Reishi) as an attractive candidate for anti-IBC therapy. Reishi contains biological compounds that are cytotoxic against cancer cells. We report the effects of Reishi on viability, apoptosis, invasion, and its mechanism of action in IBC cells (SUM-149). Results show that Reishi selectively inhibits cancer cell viability although it does not affect the viability of noncancerous mammary epithelial cells. Apoptosis induction is consistent with decreased cell viability. Reishi inhibits cell invasion and disrupts the cell spheroids that are characteristic of the IBC invasive pathology. Reishi decreases the expression of genes involved in cancer cell survival and proliferation (BCL-2, TERT, PDGFB), and invasion and metastasis (MMP-9), whereas it increases the expression of IL8. Reishi reduces BCL-2, BCL-XL, E-cadherin, eIF4G, p120-catenin, and c-Myc protein expression and gelatinase activity. These findings suggest that Reishi is an effective anti-IBC therapeutic.

The abstract can be found here on an excellent public medical resource PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Access the link here

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